Title:
気道中の生物膜を溶解するための加水分解酵素および酸化酵素の使用
Document Type and Number:
Japanese Patent JP5702601
Kind Code:
B2
Abstract:
A composition for removal of biofilm in the airway passage is useful for the treatment of infections such as pneumonia cause by Mycoplasma pneumoniae. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond that connects two monosaccharides in a polysaccharide or that connects a monosaccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the airway; and (2) a pharmaceutically acceptable carrier suitable for administration into the airway. The composition can further include ingredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a peroxidase is included, the composition can further include an oxidase to generate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an infection based on the ability of the composition to dissolve biofilm in the airway.
Inventors:
Perico, Michael, A.
Application Number:
JP2010516075A
Publication Date:
April 15, 2015
Filing Date:
January 23, 2008
Export Citation:
Assignee:
Laclade, Incorporated
International Classes:
A61K38/46; A61K31/573; A61K47/10; A61P11/00; A61P31/04; A61P43/00
Domestic Patent References:
| JP200451523A | ||||
| JP4503077A | ||||
| JP2001508677A | ||||
| JP6461427A |
Foreign References:
| WO2005120556A1 | ||||
| WO2007067520A1 | ||||
| US20020037260 |
Other References:
Microbiology.2006.04;152:913-922.
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka