Title:
麻疹−ヒトパピローマ混合ワクチン
Document Type and Number:
Japanese Patent JP5726727
Kind Code:
B2
Abstract:
The present invention relates to combined vaccines against measles and human papilloma virus (HPV). In particular, the invention relates to recombinant measles virus vectors containing heterologous nucleic acid encoding single or several antigens derived from HPV, preferably, the major capside antigen L1, the minor capside antigen L2, the early gene E6 and the early gene E7 oncoproteins of HPV type 16, and optionally of types 18, 6 and 11. In a first embodiment, prophylactic vaccines are generated expressing HPV antigens, preferably L1 and/or L2 such that they induce a potent long-lasting immune response in mammals, preferably humans, to protect against HPV and MV infection. In another embodiment, therapeutic vaccines are generated expressing E6 and E7 proteins, and optionally L1 and L2, such that they induced strong immune responses will resolve persistent HPV infections at early or late stages, including HPV-induced cervical carcinoma. In a preferred embodiment, the combined vaccines are easy to produce on a large scale and can be distributed at low cost.
Inventors:
Sanjeev Kay Mendiletta
Reinhard Grueck
Viviana Giannino
Jusepina Cantarella
Francesca Skudeli
Martin Belette
Agata Fazzio
Reinhard Grueck
Viviana Giannino
Jusepina Cantarella
Francesca Skudeli
Martin Belette
Agata Fazzio
Application Number:
JP2011511167A
Publication Date:
June 03, 2015
Filing Date:
May 26, 2009
Export Citation:
Assignee:
Cadilla Healthcare Limited
International Classes:
A61K39/295; A61K39/165; A61K39/20; A61K39/25; A61K39/39; A61K47/10
Domestic Patent References:
| JP8504087A | ||||
| JP2004531540A | ||||
| JP2008500019A | ||||
| JP2007262097A | ||||
| JP2002506045A |
Foreign References:
| WO2007120120A1 |
Other References:
TANGY F,LIVE ATTENUATED MEASLES VACCINE AS A POTENTIAL MULTIVALENT PEDIATRIC VACCINATION VECTOR,VIRAL IMMUNOLOGY,米国,MARY ANN LIEBERT, INC.,2005年 6月 1日,V18 N2,P317-326
Margaret A. Stanley,Human papillomavirus vaccines,Reviews in Medical Virology,2006年,Vol. 16,139-149
Margaret A. Stanley,Human papillomavirus vaccines,Reviews in Medical Virology,2006年,Vol. 16,139-149
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro