ＩＬ１５−Ｒα用ＩＬ−１５結合部位およびアゴニスト／アンタゴニスト活性を有する特異的ＩＬ−１５突然変異体 - Institut National De La Sante & De La Recherche Medical

Title:

ＩＬ１５−Ｒα用ＩＬ−１５結合部位およびアゴニスト／アンタゴニスト活性を有する特異的ＩＬ−１５突然変異体

Document Type and Number:

Japanese Patent JP5744369

Kind Code:

B2

Abstract:

The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

More Like This:

JP6249436	A 4-fold spiral DNA detection probe and a detecting method of 4-fold spiral structure using it
JP3243250	[Title of Invention] CRF homologue
WO/2002/003072	A METHOD FOR EXTRACTING QUANTITATIVE INFORMATION RELATING TO INTERACTIONS BETWEEN CELLULAR COMPONENTS

Inventors:

Bernard, Jerome
Pre, Ariane
Jack, Janic
Arbe, Catherine
Chemne, Agnès
Mortier, Erwan

Application Number:

JP2007500188A

Publication Date:

July 08, 2015

Filing Date:

February 10, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Institut National De La Sante & De La Recherche Medical

International Classes:

C12N15/09; A61K38/00; C07K7/06; C07K7/08; C07K14/54; C12N1/19; C12N1/21; C12N5/10

Domestic Patent References:

JP11500908A
JP2002515247A
JP2001502521A

Other References:

J.Biol.Chem.,Vol.279,No.23(2004.Jun.)p.24313-24322
J.Biol.Chem.,Vol.272,No.4(1997)p.2312-2318
Structure,Vol.2,No.9(1994)p.839-851
J.Immunol.,Vol.160,No.12(1998)p.5742-5748
Blood,Vol.97,No.1(2001)p.14-32

Attorney, Agent or Firm:

Hajime Tsukuni
Keiko Ozawa
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Suzuki Otoya

Previous Patent: カラオケ演奏のテンポ変更時における補助テンポ出力システム

Next Patent: ACOUSTIC COUPLER