Title:
血液型同定されたレシピエントに対する交差試験による、血液型が同定された輸血ドナーの選択
Document Type and Number:
Japanese Patent JP5744378
Kind Code:
B2
Abstract:
Disclosed are methods for establishing the compatibility between two blood types on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of blood types constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.
Inventors:
Chan, Yi
Seul, Michael
Seul, Michael
Application Number:
JP2008536865A
Publication Date:
July 08, 2015
Filing Date:
October 23, 2006
Export Citation:
Assignee:
Bio Array Solutions Limited
International Classes:
G01N33/50; G01N33/80; G06F19/00; G16B20/20; G16B20/40; G16B25/00; G16B40/00
Foreign References:
| US20050143928 |
Other References:
Lau, F.Y.,Provision of phenotype-matched blood units: no need for pre-transfusion antibody screening,haematologica,2001年 7月,Vol.86, No.7,p.742-748
Simon, R.,Application of optimization methods to the hematological support of patients with disseminated malignancies,Mathematical Biosciences,1975年,Vol.25, No.1-2,p.125-138
Simon, R.,Application of optimization methods to the hematological support of patients with disseminated malignancies,Mathematical Biosciences,1975年,Vol.25, No.1-2,p.125-138
Attorney, Agent or Firm:
Patent business corporation Kita Aoyama International