Title:
糖尿病性腎症の検査方法
Document Type and Number:
Japanese Patent JP5759372
Kind Code:
B2
Abstract:
Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin.
Inventors:
Masanori Hara
Ryohiko Saito
Tomino Yasumi
Katsuhiko Asanuma
Hiroyuki Kurosawa
Shinya Ogasawara
Hirayama Yoshiro
Ryohiko Saito
Tomino Yasumi
Katsuhiko Asanuma
Hiroyuki Kurosawa
Shinya Ogasawara
Hirayama Yoshiro
Application Number:
JP2011518307A
Publication Date:
August 05, 2015
Filing Date:
June 09, 2010
Export Citation:
Assignee:
Masanori Hara
Niigata University
School corporation Juntendo
Denka Seiken Co., Ltd.
Niigata University
School corporation Juntendo
Denka Seiken Co., Ltd.
International Classes:
G01N33/68; G01N33/53
Foreign References:
| WO2002037099A1 | 2002-05-10 | |||
| WO2007102787A1 | 2007-09-13 | |||
| WO2008084331A2 | 2008-07-17 |
Other References:
JPN6014029995; 原 正則: '腎疾患の診療に役立つ新しい検査 尿中ｐｏｄｏｃｙｔｅ検査，尿中ポドカリキシン定量' 腎と透析 Ｖｏｌ．６５， Ｎｏ．４, 20081025, ｐｐ． ４８８-４９１
JPN6014029996; Ｎａｋａｍｕｒａ Ｔ． ｅｔ ａｌ．: 'Ｕｒｉｎａｒｙ ｅｘｃｒｅｔｉｏｎ ｏｆ ｐｏｄｏｃｙｔｅｓ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｄｉａｂｅｔｉｃ ｎｅｐｈｒｏｐａｔｈｙ' Ｎｅｐｈｒｏｌ． Ｄｉａｌ． Ｔｒａｎｓｐｌａｎｔ． Ｖｏｌ． １５， Ｎｏ． ９, 2000, ｐｐ．１３７９-１３８３
JPN6010045638; 関根盛、 原正則: '腎障害の新しいマーカーについて-尿中ポドサイト，ポドカリキシンと臨床病理学的意義-' Ｔｈｅｒ．Ｒｅｓ． Ｖｏｌ．２９ Ｎｏ．１１, 2008, ｐ．１９００-１９０４
JPN6015007505; Ｔｓｕｋａｓａ Ｎａｋａｍｕｒａ: 'Ｐｉｏｇｌｉｔａｚｏｎｅ Ｒｅｄｕｃｅｓ Ｕｒｉｎａｒｙ Ｐｏｄｏｃｙｔｅ Ｅｘｃｒｅｔｉｏｎ ｉｎ Ｔｙｐｅ ２ Ｄｉａｂｅｔｅｓ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｍｉｃｒｏａｌｂｕｍｉｎｕｒｉａ' Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ． ５０， Ｎｏ． １０, 200110, ｐｐ． １１９３-１１９６
JPN6015007506; Ｋａｔｓｕｅ Ｋａｎｎｏ: 'Ｕｒｉｎａｒｙ ｓｅｄｉｍｅｎｔ ｐｏｄｏｃａｌｙｘｉｎ ｉｎ ｃｈｉｌｄｒｅｎ ｗｉｔｈ ｇｌｏｍｅｒｕｌａｒ ｄｉｓｅａｓｅｓ' Ｎｅｐｈｒｏｎ Ｃｌｉｎ Ｐｒａｃｔ． Ｖｏｌ． ９５, 2003, ｐｐ． ｃ９１-ｃ９９
JPN7015001364; Ｓｔｅｆａｎｉｅ Ｕ． Ｖｏｇｅｌｍａｎｎ: 'Ｕｒｉｎａｒｙ ｅｘｃｒｅｔｉｏｎ ｏｆ ｖｉａｂｌｅ ｐｏｄｏｃｙｔｅｓ ｉｎ ｈｅａｌｔｈ ａｎｄ ｒｅｎａｌ ｄｉｓｅａｓｅ' Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｒｅｎａｌ Ｐｈｙｓｉｏｌ Ｖｏｌ． ２８５, 20030311, ｐｐ． Ｆ４０-Ｆ４８
JPN7015001365; Ｍａｓａｎｏｒｉ Ｈａｒａ: 'Ａｐｉｃａｌ Ｃｅｌｌ Ｍｅｍｂｒａｎｅｓ Ａｒｅ Ｓｈｅｄ ｉｎｔｏ Ｕｒｉｎｅ ｆｒｏｍ Ｉｎｊｕｒｅｄ Ｐｏｄｏｃｙｔｅｓ： Ａ Ｎｏｖｅｌ Ｐｈｅｎｏｍｅｎｏｎ ｏｆ Ｐｏｄｏｃｙｔｅ Ｉｎｊ' Ｊ Ａｍ Ｓｏｃ Ｎｅｐｈｒｏｌ Ｖｏｌ． １６, 2005, ｐｐ． ４０８-４１６
JPN7015001366; Ｐ． ＨＡＢＡＲＡ: 'Ａ Ｎｏｖｅｌ Ｍｅｔｈｏｄ ｆｏｒ ｔｈｅ Ｅｓｔｉｍａｔｉｏｎ ｏｆ Ｐｏｄｏｃｙｔｅ Ｉｎｊｕｒｙ： Ｐｏｄｏｃａｌｙｘｉｎ-Ｐｏｓｉｔｉｖｅ Ｅｌｅｍｅｎｔｓ ｉｎ Ｕｒｉｎｅ' Ｆｏｌｉａ Ｂｉｏｌｏｇｉｃａ Ｖｏｌ． ５４, 2008, ｐｐ． １６２-１６７
JPN7015001367; ＪＪ Ｌｉ: 'Ｐｏｄｏｃｙｔｅ ｂｉｏｌｏｇｙ ｉｎ ｄｉａｂｅｔｉｃ ｎｅｐｈｒｏｐａｔｈｙ' Ｋｉｄｎｅｙ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｖｏｌ． ７２, 2007, ｐｐ． Ｓ３６-Ｓ４２
JPN6014029996; Ｎａｋａｍｕｒａ Ｔ． ｅｔ ａｌ．: 'Ｕｒｉｎａｒｙ ｅｘｃｒｅｔｉｏｎ ｏｆ ｐｏｄｏｃｙｔｅｓ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｄｉａｂｅｔｉｃ ｎｅｐｈｒｏｐａｔｈｙ' Ｎｅｐｈｒｏｌ． Ｄｉａｌ． Ｔｒａｎｓｐｌａｎｔ． Ｖｏｌ． １５， Ｎｏ． ９, 2000, ｐｐ．１３７９-１３８３
JPN6010045638; 関根盛、 原正則: '腎障害の新しいマーカーについて-尿中ポドサイト，ポドカリキシンと臨床病理学的意義-' Ｔｈｅｒ．Ｒｅｓ． Ｖｏｌ．２９ Ｎｏ．１１, 2008, ｐ．１９００-１９０４
JPN6015007505; Ｔｓｕｋａｓａ Ｎａｋａｍｕｒａ: 'Ｐｉｏｇｌｉｔａｚｏｎｅ Ｒｅｄｕｃｅｓ Ｕｒｉｎａｒｙ Ｐｏｄｏｃｙｔｅ Ｅｘｃｒｅｔｉｏｎ ｉｎ Ｔｙｐｅ ２ Ｄｉａｂｅｔｅｓ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｍｉｃｒｏａｌｂｕｍｉｎｕｒｉａ' Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ． ５０， Ｎｏ． １０, 200110, ｐｐ． １１９３-１１９６
JPN6015007506; Ｋａｔｓｕｅ Ｋａｎｎｏ: 'Ｕｒｉｎａｒｙ ｓｅｄｉｍｅｎｔ ｐｏｄｏｃａｌｙｘｉｎ ｉｎ ｃｈｉｌｄｒｅｎ ｗｉｔｈ ｇｌｏｍｅｒｕｌａｒ ｄｉｓｅａｓｅｓ' Ｎｅｐｈｒｏｎ Ｃｌｉｎ Ｐｒａｃｔ． Ｖｏｌ． ９５, 2003, ｐｐ． ｃ９１-ｃ９９
JPN7015001364; Ｓｔｅｆａｎｉｅ Ｕ． Ｖｏｇｅｌｍａｎｎ: 'Ｕｒｉｎａｒｙ ｅｘｃｒｅｔｉｏｎ ｏｆ ｖｉａｂｌｅ ｐｏｄｏｃｙｔｅｓ ｉｎ ｈｅａｌｔｈ ａｎｄ ｒｅｎａｌ ｄｉｓｅａｓｅ' Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｒｅｎａｌ Ｐｈｙｓｉｏｌ Ｖｏｌ． ２８５, 20030311, ｐｐ． Ｆ４０-Ｆ４８
JPN7015001365; Ｍａｓａｎｏｒｉ Ｈａｒａ: 'Ａｐｉｃａｌ Ｃｅｌｌ Ｍｅｍｂｒａｎｅｓ Ａｒｅ Ｓｈｅｄ ｉｎｔｏ Ｕｒｉｎｅ ｆｒｏｍ Ｉｎｊｕｒｅｄ Ｐｏｄｏｃｙｔｅｓ： Ａ Ｎｏｖｅｌ Ｐｈｅｎｏｍｅｎｏｎ ｏｆ Ｐｏｄｏｃｙｔｅ Ｉｎｊ' Ｊ Ａｍ Ｓｏｃ Ｎｅｐｈｒｏｌ Ｖｏｌ． １６, 2005, ｐｐ． ４０８-４１６
JPN7015001366; Ｐ． ＨＡＢＡＲＡ: 'Ａ Ｎｏｖｅｌ Ｍｅｔｈｏｄ ｆｏｒ ｔｈｅ Ｅｓｔｉｍａｔｉｏｎ ｏｆ Ｐｏｄｏｃｙｔｅ Ｉｎｊｕｒｙ： Ｐｏｄｏｃａｌｙｘｉｎ-Ｐｏｓｉｔｉｖｅ Ｅｌｅｍｅｎｔｓ ｉｎ Ｕｒｉｎｅ' Ｆｏｌｉａ Ｂｉｏｌｏｇｉｃａ Ｖｏｌ． ５４, 2008, ｐｐ． １６２-１６７
JPN7015001367; ＪＪ Ｌｉ: 'Ｐｏｄｏｃｙｔｅ ｂｉｏｌｏｇｙ ｉｎ ｄｉａｂｅｔｉｃ ｎｅｐｈｒｏｐａｔｈｙ' Ｋｉｄｎｅｙ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｖｏｌ． ７２, 2007, ｐｐ． Ｓ３６-Ｓ４２
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga