Title:
組換え生産されたアレルゲン
Document Type and Number:
Japanese Patent JP5793138
Kind Code:
B2
Abstract:
Methods for producing an allergen composition, methods for in vitro diagnosis of type I allergy, and diagnostic kits for performing diagnosis employ Bos d 23k allergen of SEQ ID NO: 4, or the mature protein thereof, or a variant or fragment of the Bos d 23k allergen or the mature protein sharing epitopes for antibodies with the Bos d 23k allergen or the mature protein. Methods for treatment of a Type I allergy to a mammal and pharmaceutical compositions employ a Bos d 23k allergen of SEQ ID NO: 4, or the mature protein thereof, or a variant or fragment of the Bos d 23k allergen or the mature protein sharing epitopes for antibodies with the Bos d 23k allergen or the mature protein, wherein the Bos d 23k allergen, the mature protein, the variant or the fragment is modified to abrogate or attenuate its IgE binding response.
Inventors:
Mattson, Lars
Jonas, Ridholm
Lund Glen, Thomas
Jonas, Ridholm
Lund Glen, Thomas
Application Number:
JP2012513906A
Publication Date:
October 14, 2015
Filing Date:
June 04, 2010
Export Citation:
Assignee:
Phadia Activolag
International Classes:
C12N15/09; A61K38/00; A61K39/00; A61P37/08; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53
Other References:
J Allergy Clin Immunol., 2009年2月, 第123巻, 362-368ページ
Clin Exp Allergy., 2004年, 第34巻, 1576-1582ページ
Allergy, 1996年, 第51巻, 378-382ページ
LUNDGREN T et al., Cloning and characterisation of the dog allergen Can f 4, Allergy[online], 2009年5月18日, 第64巻, S90号, 251ページ
GenBank[online], Accession No.XP_581277, PREDICTED: similar to odorant binding protein [Bos taurus], 2008年7月29日,
Clin Exp Allergy., 1992年, 第22巻, 83-90ページ
Int Arch Allergy Immunol., 1992年, 第99巻, 112-117ページ
MATTSSON L et al., Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander, Clin Exp Allergy.[online], 第40巻, 1276-1287ページ, 2010年6月10日オンライン公開,
Clin Exp Allergy., 2004年, 第34巻, 1576-1582ページ
Allergy, 1996年, 第51巻, 378-382ページ
LUNDGREN T et al., Cloning and characterisation of the dog allergen Can f 4, Allergy[online], 2009年5月18日, 第64巻, S90号, 251ページ
GenBank[online], Accession No.XP_581277, PREDICTED: similar to odorant binding protein [Bos taurus], 2008年7月29日,
Clin Exp Allergy., 1992年, 第22巻, 83-90ページ
Int Arch Allergy Immunol., 1992年, 第99巻, 112-117ページ
MATTSSON L et al., Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander, Clin Exp Allergy.[online], 第40巻, 1276-1287ページ, 2010年6月10日オンライン公開,
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama