Title:
アレルギー治療のための核酸
Document Type and Number:
Japanese Patent JP5807994
Kind Code:
B2
Abstract:
The present invention provides DNA vaccines for the treatment of allergies. The vaccines comprise the coding sequence for one or more allergenic epitopes, and preferably the full protein sequence, of the allergenic protein from which the epitope(s) is derived, fused in-frame with the lumenal domain of the lysosomal associated membrane protein (LAMP) and the targeting sequence of LAMP. The vaccines allow for presentation of properly configured three dimensional epitopes for production of an immune response. The vaccines can be multivalent molecules, and/or can be provided as part of a multivalent vaccine containing two or more DNA constructs.
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Inventors:
Haar, william
Highland terry
Highland terry
Application Number:
JP2015517226A
Publication Date:
November 10, 2015
Filing Date:
June 15, 2012
Export Citation:
Assignee:
IMMUNOMIC THERAPEUTICS, INC.
International Classes:
A61K31/7088; C12N15/09; A61K39/36; A61P37/08
Foreign References:
| WO2002080851A1 | ||||
| WO2001076642A1 | ||||
| WO2007024026A1 | ||||
| WO2009040443A1 |
Other References:
KABURAKI, Y. et al.,Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide.,Comp. Immunol. Microbiol. Infect. Dis. ,2011年,Vol.34 No.2,pages 157-161
ISHII, M. et al.,Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice.,Internat. Immunopharm.,2010年,Vol.10 No.9,pages 1041-1046
TSUNEMATSU, M. et al.,Allergol. Int.,Effect of Cry-consensus peptide, a novel recombinant peptide for immunotherapy of Japanese cedar pollinosis, on an experimental allergic rhinitis model in B10.S mice.,2007年,Vol.56 No.4,pages 465-472
TODA, M. et al.,DNA vaccine using invariant chain gene for delivery of CD4+ T cell epitope peptide derived from Japanese cedar pollen allergen inhibits allergen-specific IgE response.,Eur. J. Immunol.,2002年,Vol.32 No.6,pages 1631-1639
KOHAMA, Y. et al. ,Immunostimulatory oligodeoxynucleotide induces TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice.,J. Allergy Clin. Immunol.,1999年,Vol.104 No.6,pages 1231-1238
KOHNO, K. et al.,Regulation of cytokine production by sugi allergen-pullulan conjugate.,Cell. Immunol.,1996年,Vol.168 No.2,pages 211-219
TAKENO, M. et al.,Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model.,Clin. Experiment. Allergy,2004年,Vol.34 No.6,pages 965-970
山下 直美 他,Th1細胞の誘導法,医学のあゆみ,1997年,Vol.180 No.1,pages 85-89
ISHII, M. et al.,Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice.,Internat. Immunopharm.,2010年,Vol.10 No.9,pages 1041-1046
TSUNEMATSU, M. et al.,Allergol. Int.,Effect of Cry-consensus peptide, a novel recombinant peptide for immunotherapy of Japanese cedar pollinosis, on an experimental allergic rhinitis model in B10.S mice.,2007年,Vol.56 No.4,pages 465-472
TODA, M. et al.,DNA vaccine using invariant chain gene for delivery of CD4+ T cell epitope peptide derived from Japanese cedar pollen allergen inhibits allergen-specific IgE response.,Eur. J. Immunol.,2002年,Vol.32 No.6,pages 1631-1639
KOHAMA, Y. et al. ,Immunostimulatory oligodeoxynucleotide induces TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice.,J. Allergy Clin. Immunol.,1999年,Vol.104 No.6,pages 1231-1238
KOHNO, K. et al.,Regulation of cytokine production by sugi allergen-pullulan conjugate.,Cell. Immunol.,1996年,Vol.168 No.2,pages 211-219
TAKENO, M. et al.,Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model.,Clin. Experiment. Allergy,2004年,Vol.34 No.6,pages 965-970
山下 直美 他,Th1細胞の誘導法,医学のあゆみ,1997年,Vol.180 No.1,pages 85-89
Attorney, Agent or Firm:
Norio Saeki
Yuko Saeki
Nakamura Tadashi Exhibition
Takuro Saeki
Naoko Ushiyama
Yuko Saeki
Nakamura Tadashi Exhibition
Takuro Saeki
Naoko Ushiyama