Title:
Ａβオリゴマーに特異的に結合する抗体およびその利用
Document Type and Number:
Japanese Patent JP5812418
Kind Code:
B2
Abstract:
The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
Inventors:
Yokoseki Tatsumi
Yasuhide Okamoto
Makoto Umeda
Toshiyuki Ito
Yukio Imai
Shinobu Fujii
Takafumi Naofumi
Yasuhide Okamoto
Makoto Umeda
Toshiyuki Ito
Yukio Imai
Shinobu Fujii
Takafumi Naofumi
Application Number:
JP2011544303A
Publication Date:
November 11, 2015
Filing Date:
April 16, 2010
Export Citation:
Assignee:
Imnas Pharma Co., Ltd.
International Classes:
C07K16/18; A61K39/395; A61P25/00; A61P25/28; A61P43/00
Foreign References:
| WO2008150946A1 | ||||
| WO2003104437A1 |
Other References:
FEBS Letters,2009年 1月20日,Vol.583,P.579-584
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto