Title:
２，５，６，７−テトラヒドロ−［１，４］オキサゼピン−３−イルアミン又は２，３，６，７−テトラヒドロ−［１，４］オキサゼピン−５−イルアミン化合物
Document Type and Number:
Japanese Patent JP5823503
Kind Code:
B2
Abstract:
This invention relates to compounds of the formula wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.
Inventors:
Banner, david
Gouva, Wolfgang
Hilpelt, Hans
Hum, roland
Mouser, halalt
Myvek, alexander fao
Narquisian, Robert
Power, ian
Rogers-Evans, Mark
Ronbach, Didier
Voltering, Thomas
Vostol, Wolfgang
Gouva, Wolfgang
Hilpelt, Hans
Hum, roland
Mouser, halalt
Myvek, alexander fao
Narquisian, Robert
Power, ian
Rogers-Evans, Mark
Ronbach, Didier
Voltering, Thomas
Vostol, Wolfgang
Application Number:
JP2013509501A
Publication Date:
November 25, 2015
Filing Date:
May 03, 2011
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
SIENA BIOTECH S.P.A
SIENA BIOTECH S.P.A
International Classes:
C07D267/10; A61K31/553; A61P1/00; A61P7/02; A61P9/10; A61P17/00; A61P19/02; A61P21/00; A61P21/02; A61P25/00; A61P25/14; A61P25/28; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07D413/12; C07D417/12
Domestic Patent References:
| JP2013500247A |
Foreign References:
| EP2147914A1 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Hajime Tsukuni
Yasuo Yanagibashi
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata