Title:
置換2,3−ジヒドロイミダゾ[1,2−C]キナゾリン塩類
Document Type and Number:
Japanese Patent JP5826961
Kind Code:
B2
Abstract:
The present invention relates :
- to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II) :
or a tautomer, solvate or hydrate thereof ;
- to methods of preparing said dihydrochloride salt ;
- to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;
- to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer ;
- to a pharmaceutical composition comprising said dihydrochloride salt ; and
- to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
Inventors:
Jan Georg Peters
Hans-Christian Militzer
Hartwig Mueller
Hans-Christian Militzer
Hartwig Mueller
Application Number:
JP2015091455A
Publication Date:
December 02, 2015
Filing Date:
April 28, 2015
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
C07D487/04; A61K31/5377; A61K45/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
JP2014510119A |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Yoshikazu Iwase
Yasufumi Shiroyama
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