Title:
２，５−置換されたオキサゾロピリミジン環を有する複素環式カルボン酸誘導体
Document Type and Number:
Japanese Patent JP5841068
Kind Code:
B2
Abstract:
Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonists The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
Inventors:
Dieter Cardellite
Matthias Schaefer
Stefani Hacktel
Axel Dietrich
Thomas Hoop Shri
Katrin Hiss
Matthias Schaefer
Stefani Hacktel
Axel Dietrich
Thomas Hoop Shri
Katrin Hiss
Application Number:
JP2012548411A
Publication Date:
January 06, 2016
Filing Date:
January 12, 2011
Export Citation:
Assignee:
SANOFI
International Classes:
C07D498/04; A61K31/519; A61P3/10; A61P17/02
Domestic Patent References:
| JP2009520688A | ||||
| JP2006528698A | ||||
| JP2009506046A | ||||
| JP2006524662A | ||||
| JP2011527994A | ||||
| JP2013517243A | ||||
| JP2013517241A | ||||
| JP2013517239A | ||||
| JP2013517238A | ||||
| JP2013517240A |
Foreign References:
| WO2009154775A1 | ||||
| WO2007109334A1 |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi