Title:
ＰＲＰＫ−ＴＰＲＫＢモジュレーター及びその使用
Document Type and Number:
Japanese Patent JP5857043
Kind Code:
B2
Abstract:
The present invention provides methods of identifying an agent that modulates PRPK, TPRKB, OSGEP, LAGE3 and its homologs, PRPK/TPRKB complex, and/or KEOPS complex. The present invention also provides compositions of such agents and methods of treating a disease, disorder, or condition associated with PRPK, TPRKB, OSGEP, LAGE3 and its homologs family (CT antigens), PRPK/TPRKB complex, and/or KEOPS complex using such an agent or composition.
Inventors:
Park, Eun, Sun
Perish, Henry, Yi.
Clark, Astrid, S.
Williams, Grace, Elle.
Castardi, Maria, Paola
Alfolo, alexander
Ring, Jennifer, Yi.
Share, Matthew, Dee.
King, Randle, W.
Perish, Henry, Yi.
Clark, Astrid, S.
Williams, Grace, Elle.
Castardi, Maria, Paola
Alfolo, alexander
Ring, Jennifer, Yi.
Share, Matthew, Dee.
King, Randle, W.
Application Number:
JP2013515555A
Publication Date:
February 10, 2016
Filing Date:
June 17, 2011
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
G01N33/50; A61K31/454; A61K45/00; A61P1/04; A61P17/02; A61P19/02; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C12P21/00; G01N33/15; G01N33/566
Domestic Patent References:
| JP2007505922A | ||||
| JP2007510670A |
Other References:
Yasuhito Abe,他,A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK,Biochemical and Biophysical Research Communications,ELSEVIER,2006年 3月22日,Vol.344/Issue 1,p377-385
Akifumi Miyoshi,他,Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein,Biochemical and Biophysical Research Communications,ELSEVIER,2003年 4月 4日,Vol.303/Issue 2,p399-405
G. Manning,他,The Protein Kinase Complementof the Human Genome,SCIENCE,米国,American Association for the Advancement of Science ,2002年12月 6日,Vol.298/Issue 5600,p1912-1934
Daniel Y.L. Mao,他,Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine,Molecular Cell,ELSEVIER,2008年10月24日,Vol.32/Issue 2,p259-275
Akifumi Miyoshi,他,Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein,Biochemical and Biophysical Research Communications,ELSEVIER,2003年 4月 4日,Vol.303/Issue 2,p399-405
G. Manning,他,The Protein Kinase Complementof the Human Genome,SCIENCE,米国,American Association for the Advancement of Science ,2002年12月 6日,Vol.298/Issue 5600,p1912-1934
Daniel Y.L. Mao,他,Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine,Molecular Cell,ELSEVIER,2008年10月24日,Vol.32/Issue 2,p259-275
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto