Title:
ＡＰＥ１／ＲＥＦ−１を含有する膀胱癌診断用組成物、及びこれを利用した膀胱癌診断キット
Document Type and Number:
Japanese Patent JP5857385
Kind Code:
B2
Abstract:
Provided are a bladder cancer diagnosis composition containing APE1/Ref-1, a bladder cancer diagnostic kit containing an antibody which specifically binds to the APE1/Ref-1, and a method of measuring APE1/Ref-1 concentration in biological samples through an antigen-antibody binding reaction using the antibody which specifically binds to the APE1/Ref-1. According to the invention, the APE1/Ref-1 protein concentration in serum of bladder cancer patients is significantly higher than in healthy subjects, and more particularly, it significantly increases in the serum of patients with stage 2 or later bladder cancer.
Inventors:
John Byung Hwa
Choi, Suna
Shin, Ju Hyun
Choi, Suna
Shin, Ju Hyun
Application Number:
JP2013541933A
Publication Date:
February 10, 2016
Filing Date:
December 08, 2011
Export Citation:
Assignee:
The Industry and Academy Cooperation in Chunnam National University
International Classes:
G01N33/574
Domestic Patent References:
| JP2007314493A | ||||
| JP2010521688A |
Foreign References:
| WO2010092079A1 |
Other References:
Salim E.L et al,Elevated oxidative stress and DNA damage and repair levels in urinary Bladder carcinomas associated with Schistomiasis,International Journal of Cancer,2008年,123,601-608
斉魯医学雑誌,2009年,第24巻第3期,230-232
Sak SC et al,APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer,Clin Cancer Res,2005年 9月 1日,11(17),6205-6211
斉魯医学雑誌,2009年,第24巻第3期,230-232
Sak SC et al,APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer,Clin Cancer Res,2005年 9月 1日,11(17),6205-6211
Attorney, Agent or Firm:
Takahisa Kimura