関節痛の治療のためのコルチコステロイド

Title:

関節痛の治療のためのコルチコステロイド

Document Type and Number:

Japanese Patent JP5873492

Kind Code:

B2

Abstract:

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous Cortisol production.

Inventors:

Bodick nail
Blanks Robert Sea.
Kumar Anjali
Clayman Michael Dee.
Moran mark

Application Number:

JP2013523336A

Publication Date:

March 01, 2016

Filing Date:

August 04, 2011

Export Citation:

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Assignee:

Flexion Therapeutics Incorporated

International Classes:

A61K31/58; A61K9/16; A61K47/34; A61P19/02; A61P19/06; A61P25/04; A61P29/00

Domestic Patent References:

JP2006503865A
JP11222425A
JP2007533634A

Foreign References:

WO2008157057A1
WO2009026539A1
US20070298073

Other References:

Int. J. Pharm.,2009年,Vol.368,pp.45-55
Pharm. Res.,2002年,Vol.19 No.4,pp.403-409
AAPS PharmSciTech.,2010年 6月,Vol.11 No.2,pp.859-869
Biomaterials,2002年,Vol.23,pp.1649-1656

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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