Title:
抗体定常領域改変体
Document Type and Number:
Japanese Patent JP5889181
Kind Code:
B2
Abstract:
The present inventors carried out dedicated research to generate antibody constant regions with reduced Fc³ receptor-binding activity by altering amino acid sequences in the antibody constant region. As a result, the present inventors successfully identified novel constant region sequences with reduced Fc³ receptor-binding activity compared to conventional antibody constant regions.
Inventors:
Taichi Kuramochi
Tomoyuki Ikawa
Atsuhiko Maeda
Ajmoto Futa
Tomoyuki Ikawa
Atsuhiko Maeda
Ajmoto Futa
Application Number:
JP2012503293A
Publication Date:
March 22, 2016
Filing Date:
March 04, 2011
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C12N15/09; A61K39/395; A61P37/00; C07K16/00
Domestic Patent References:
| JP2002514406A | 2002-05-21 | |||
| JP2008512995A | 2008-05-01 | |||
| JP2009500458A | 2009-01-08 |
Foreign References:
| WO2009041062A1 | 2009-04-02 | |||
| WO2009041613A1 | 2009-04-02 | |||
| WO2006033386A1 | 2006-03-30 | |||
| WO2009072604A1 | 2009-06-11 | |||
| WO2011090762A1 | 2011-07-28 |
Other References:
JPN6011022342; Ｉｍｍｕｎｏｌ． Ｌｅｔｔ．， （１９９５）， ４４， ［２-３］， ｐ．１１１-１１７
JPN6011022345; Ｍｏｌ． Ｉｍｍｕｎｏｌ．， （１９９２）， ２９， ［５］， ｐ．６３３-６３９
JPN6015013915; Ｊ． Ｉｍｍｕｎｏｌ．， （１９９７）， １５９， ［７］， ｐ．３６１３-３６２１
JPN6015043861; Ｅｕｒ． Ｊ． Ｉｍｍｕｎｏｌ．， （１９９３）， ２３， ［５］， ｐ．１０９８-１１０４
JPN6011022345; Ｍｏｌ． Ｉｍｍｕｎｏｌ．， （１９９２）， ２９， ［５］， ｐ．６３３-６３９
JPN6015013915; Ｊ． Ｉｍｍｕｎｏｌ．， （１９９７）， １５９， ［７］， ｐ．３６１３-３６２１
JPN6015043861; Ｅｕｒ． Ｊ． Ｉｍｍｕｎｏｌ．， （１９９３）， ２３， ［５］， ｐ．１０９８-１１０４
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto