Title:
多能性幹細胞から分化誘導された細胞の生産方法
Document Type and Number:
Japanese Patent JP5896457
Kind Code:
B2
Abstract:
Disclosed is a method for producing target cells that have been induced to differentiate from pluripotent stem cells, which involves a process for implanting pluripotent stem cells derived from a mammalian individual into a non-human mammal, a process for dosing the aforementioned non-human mammal with an agent for inducing differentiation into target cells, a process for raising the aforementioned non-human mammal long enough for the implanted pluripotent stem cells to form teratomas in vivo in said mammal and for inducing the aforementioned pluripotent stem cells to differentiate into the target cells, and a process for recovering the target cells derived from the aforementioned mammalian individual from the aforementioned non-human mammal.
Inventors:
Hiromitsu Nakauchi
Kamiya Satoshi
Naho Suzuki
Keiichi Ito
Kamiya Satoshi
Naho Suzuki
Keiichi Ito
Application Number:
JP2011545228A
Publication Date:
March 30, 2016
Filing Date:
December 08, 2010
Export Citation:
Assignee:
National University Corporation Tokyo University
International Classes:
C12N5/10
Domestic Patent References:
| JP2006506047A | 2006-02-23 |
Other References:
JPN5011001607; ＴＡＫＡＨＡＳＨＩ， Ｋ．， ｅｔ ａｌ．: ＣＥＬＬ Ｖｏ．１３１， Ｎｏ．５, 20071130, ｐｐ．８６１-８７２, ＣＥＬＬ ＰＲＥＳＳ
JPN6011014247; ＴＡＫＡＨＡＳＨＩ， Ｋ．， ｅｔ ａｌ．: Ｃｅｌｌ Ｖｏｌ．１２６, 2006, ｐｐ．６６３-６７６
JPN6011014244; ＳＡＳＡＫＩ， Ｋ．， ｅｔ ａｌ．: Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．７９， Ｎｏ．１, 2005, ｐｐ．３２-３７
JPN6011014245; ＤＲＥＷＥＬ， Ｄ．， ｅｔ ａｌ．: Ｃｙｔｏｔｈｅｒａｐｙ Ｖｏｌ．８， Ｎｏ．１, 2006, ｐｐ．７０-７８
JPN6011014246; ＦＲＵＴＨ， Ｍ．Ｅ．， ｅｔ ａｌ．: Ｊ．Ｃｅｌｌ．Ｂｉｏｃｈｅｍ． Ｖｏｌ．１０６， Ｎｏ．４, 20090107, ｐｐ．５０７-５１１
JPN6011014248; ＴＡＫＩＺＡＷＡ， Ｈ．， ｅｔ ａｌ．: Ｉｎｆｌａｍｍａｔｉｏｎ ａｎｄ Ｒｅｇｅｎｅｒａｔｉｏｎ Ｖｏｌ．２７， Ｎｏ．１, 200701, ｐｐ．５９-６４
JPN6011014249; ＳＥＩＴＡ， Ｊ．， ｅｔ ａｌ．: Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ Ｖｏｌ．１０４， Ｎｏ．７, 2007, ｐｐ．２３４９-２３５４
JPN6011014250; 花園豊: ＢＩＯ Ｉｎｄ． Ｖｏｌ．２５， Ｎｏ．１２, 2008, ｐｐ．７６-８０．６
JPN6011014251; ＨＡＭＡＺＡＫＩ， Ｔ．， ｅｔ ａｌ．: ＦＥＢＳ Ｌｅｔｔ． Ｖｏｌ．４９７, 2001, ｐｐ．１５-１９
JPN6011014252; ＳＨＩＲＡＫＩ， Ｎ．， ｅｔ ａｌ．: Ｇｅｎｅｓ ｔｏ Ｃｅｌｌｓ Ｖｏｌ．１３, 2008, ｐｐ．７３１-７４６
JPN6011014254; ＬＡＶＯＮ， Ｎ．， ｅｔ ａｌ．: Ｓｔｅｍ Ｃｅｌｌｓ Ｖｏｌ．２４, 2006, ｐｐ．１９２３-１９３０
JPN6011014255; ＺＨＡＮＧ， Ｄ．， ｅｔ ａｌ．: Ｃｅｌｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１９， Ｎｏ．４, 20090303, ｐｐ．４２９-４３８
JPN6011014256; ＨＥＮＴＺＥ， Ｈ．， ｅｔ ａｌ．: Ｓｔｅｍ Ｃｅｌｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．２， Ｎｏ．３, 200905, ｐｐ．１９８-２１０
JPN6011014247; ＴＡＫＡＨＡＳＨＩ， Ｋ．， ｅｔ ａｌ．: Ｃｅｌｌ Ｖｏｌ．１２６, 2006, ｐｐ．６６３-６７６
JPN6011014244; ＳＡＳＡＫＩ， Ｋ．， ｅｔ ａｌ．: Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．７９， Ｎｏ．１, 2005, ｐｐ．３２-３７
JPN6011014245; ＤＲＥＷＥＬ， Ｄ．， ｅｔ ａｌ．: Ｃｙｔｏｔｈｅｒａｐｙ Ｖｏｌ．８， Ｎｏ．１, 2006, ｐｐ．７０-７８
JPN6011014246; ＦＲＵＴＨ， Ｍ．Ｅ．， ｅｔ ａｌ．: Ｊ．Ｃｅｌｌ．Ｂｉｏｃｈｅｍ． Ｖｏｌ．１０６， Ｎｏ．４, 20090107, ｐｐ．５０７-５１１
JPN6011014248; ＴＡＫＩＺＡＷＡ， Ｈ．， ｅｔ ａｌ．: Ｉｎｆｌａｍｍａｔｉｏｎ ａｎｄ Ｒｅｇｅｎｅｒａｔｉｏｎ Ｖｏｌ．２７， Ｎｏ．１, 200701, ｐｐ．５９-６４
JPN6011014249; ＳＥＩＴＡ， Ｊ．， ｅｔ ａｌ．: Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ Ｖｏｌ．１０４， Ｎｏ．７, 2007, ｐｐ．２３４９-２３５４
JPN6011014250; 花園豊: ＢＩＯ Ｉｎｄ． Ｖｏｌ．２５， Ｎｏ．１２, 2008, ｐｐ．７６-８０．６
JPN6011014251; ＨＡＭＡＺＡＫＩ， Ｔ．， ｅｔ ａｌ．: ＦＥＢＳ Ｌｅｔｔ． Ｖｏｌ．４９７, 2001, ｐｐ．１５-１９
JPN6011014252; ＳＨＩＲＡＫＩ， Ｎ．， ｅｔ ａｌ．: Ｇｅｎｅｓ ｔｏ Ｃｅｌｌｓ Ｖｏｌ．１３, 2008, ｐｐ．７３１-７４６
JPN6011014254; ＬＡＶＯＮ， Ｎ．， ｅｔ ａｌ．: Ｓｔｅｍ Ｃｅｌｌｓ Ｖｏｌ．２４, 2006, ｐｐ．１９２３-１９３０
JPN6011014255; ＺＨＡＮＧ， Ｄ．， ｅｔ ａｌ．: Ｃｅｌｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１９， Ｎｏ．４, 20090303, ｐｐ．４２９-４３８
JPN6011014256; ＨＥＮＴＺＥ， Ｈ．， ｅｔ ａｌ．: Ｓｔｅｍ Ｃｅｌｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．２， Ｎｏ．３, 200905, ｐｐ．１９８-２１０
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Yukitaka Nakamura