Title:
経口投与用医薬組成物
Document Type and Number:
Japanese Patent JP5900702
Kind Code:
B2
Abstract:
A pharmaceutical composition containing, as the active ingredient, 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, of which the solubility in an acidic pH region is different from that in a neutral pH region, with rapid disintegration property and rapid drug dissolution property as well as the expectation of a good drug dosing compliance, is provided. The pharmaceutical composition for oral administration of the present invention contains 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide or a pharmaceutically acceptable salt thereof, and a hydrophilic lubricant, and is useful as a pharmaceutical composition for oral administration with rapid disintegration property and rapid drug dissolution property as well as the expectation of a good drug dosing compliance.
Inventors:
High E
Hiroyuki Kojima
Atsushi Sakurai
Tetsuya Tamura
Hiroo Tasaki
Atsushi Muro
Hiroyuki Kojima
Atsushi Sakurai
Tetsuya Tamura
Hiroo Tasaki
Atsushi Muro
Application Number:
JP2015508747A
Publication Date:
April 06, 2016
Filing Date:
March 28, 2014
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
A61K31/437; A61K9/20; A61K9/30; A61K47/14; A61K47/20; A61K47/34; A61P9/10; A61P17/06; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P37/08
Domestic Patent References:
| JP2009522206A | 2009-06-11 | |||
| JP2004131393A | 2004-04-30 |
Foreign References:
| WO2013022059A1 | 2013-02-14 | |||
| WO2012002547A1 | 2012-01-05 |
Attorney, Agent or Firm:
Kenichi Morita
Kenjiro Yamaguchi
Morita Taku
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke
Koichiro Morihira
Shuya Kawahama
Kenjiro Yamaguchi
Morita Taku
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke
Koichiro Morihira
Shuya Kawahama