Title:
キナーゼインヒビターの合成および使用
Document Type and Number:
Japanese Patent JP5923499
Kind Code:
B2
Abstract:
An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
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Inventors:
Ray, Ession
Behrens, Carl Henry
Lee, Hui-in
Sun, Connie El.
Behrens, Carl Henry
Lee, Hui-in
Sun, Connie El.
Application Number:
JP2013518575A
Publication Date:
May 24, 2016
Filing Date:
June 28, 2011
Export Citation:
Assignee:
Bella Stem Incorporated
International Classes:
C07D213/74
Foreign References:
| WO2008115369A1 | ||||
| WO2009153589A1 | ||||
| WO2009105498A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto