Title:
免疫調節活性を有する細胞集団、単離方法および使用
Document Type and Number:
Japanese Patent JP5925408
Kind Code:
B2
Abstract:
The present invention provides a population of connective tissue derived cells that respond to interferon-gamma (IFN-³) by expressing indolamine-2,3-dioxygenase (IDO) for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to, autoimmune diseases, inflammatory disorders, and immunologically mediated diseases including rejection of transplanted organs and tissues.
Inventors:
Dirk, Busher
Manuel, Angel, Gonzalez, De, La, Pena
Mario, Delgado, Mora
Manuel, Angel, Gonzalez, De, La, Pena
Mario, Delgado, Mora
Application Number:
JP2008531620A
Publication Date:
May 25, 2016
Filing Date:
September 22, 2006
Export Citation:
Assignee:
TIGENIX S.A.U.
International Classes:
C12N5/0775; A61K35/28; A61K39/00; A61P1/04; A61P19/02; A61P29/00; A61P37/06; C12N5/0783; A61K35/12
Domestic Patent References:
| JP2005508393A |
Foreign References:
| WO1996023058A1 |
Other References:
Tissue Eng.,2001,7(2),p.211-28
Blood,2005-FEB,105(4),p.1815-22
Blood,2004,103(12),p.4619-21
J.Lab.Clin.Med.,2004,143(5),p.284-91
Gut,2000,46(6),p.869-72
Biol.Blood Marrow Transplant.,2005,11(5),p.321-34
Joint Bone Spine,2003,70(6),p.483-5
Ann.Rheum.Dis.,2001,60(4),p.305-9
Daniel A. De Ugarte et al.、Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow、Immunology Letters、2003.発行、89、267-270
Blood,2005-FEB,105(4),p.1815-22
Blood,2004,103(12),p.4619-21
J.Lab.Clin.Med.,2004,143(5),p.284-91
Gut,2000,46(6),p.869-72
Biol.Blood Marrow Transplant.,2005,11(5),p.321-34
Joint Bone Spine,2003,70(6),p.483-5
Ann.Rheum.Dis.,2001,60(4),p.305-9
Daniel A. De Ugarte et al.、Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow、Immunology Letters、2003.発行、89、267-270
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Hiroshi Sorimachi
Yukitaka Nakamura
Noritaka Yokota
Hiroshi Sorimachi