Title:
骨形成促進剤
Document Type and Number:
Japanese Patent JP5925768
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide an osteogenesis promoter for directly promoting osteogenesis by osteoblasts, and an agent for preventing and treating bone disease. The present invention is characterized in that a binding inhibitor substance of semaphorin 4D and plexin B1 is used. For the binding inhibitor substance, suitable examples include anti-semaphorin 4D antibody, anti-plexin B1 antibody, and protein comprising the extracellular domain of plexin B1
Inventors:
Hiroshi Takayanagi
Takako Negishi
Takako Negishi
Application Number:
JP2013514986A
Publication Date:
May 25, 2016
Filing Date:
May 11, 2012
Export Citation:
Assignee:
Tokyo Medical And Dental University, Medical Hospital
International Classes:
A61K45/00; A61K38/00; A61K39/395; A61P19/00; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| JP2007308465A | 2007-11-29 | |||
| JP2001157583A | 2001-06-12 |
Other References:
JPN6012034689; Ｙ ＩＴＯ ｅｔ ａｌ．: 'Ｓｅｍａ４Ｄ／Ｐｌｅｘｉｎ-Ｂ１ ａｃｔｉｖａｔｅｓ ＰＴＥＮ ｖｉａ Ｒ-Ｒａｓ ＧＡＰ ａｃｔｉｖｉｔｙ，ｉｎｄｕｃｉｎｇ ｇｒｏｗｔｈ ｃｏｎｅ ｃｏｌｌａｐｓｅ' 神経化学 Ｖｏｌ．４６，Ｎｏ．２，３, 2007, ｐ．５２１，Ｐ２-ｄ１８
JPN6012034690; 廣谷睦他: 'セマフォリン４Ｄとその受容体プレキシンＢ１の細胞内情報伝達系の解析' 神経化学 Ｖｏｌ．４０，Ｎｏ．２／３, 2001, ｐ．２６９，ＰＡ１-０４６
JPN6012034691; 佐藤毅他: '骨細胞におけるｓｅｍａｐｈｏｒｉｎシグナルの検討' 日本口腔科学会雑誌 第６０巻第１号, 20110110, １１２ページ ２-Ｄ-１７
JPN6012034690; 廣谷睦他: 'セマフォリン４Ｄとその受容体プレキシンＢ１の細胞内情報伝達系の解析' 神経化学 Ｖｏｌ．４０，Ｎｏ．２／３, 2001, ｐ．２６９，ＰＡ１-０４６
JPN6012034691; 佐藤毅他: '骨細胞におけるｓｅｍａｐｈｏｒｉｎシグナルの検討' 日本口腔科学会雑誌 第６０巻第１号, 20110110, １１２ページ ２-Ｄ-１７
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi