Title:
オレアノール酸アセテートを有効成分として含むＴＬＲ及びＩＬ−６媒介性疾患の予防又は治療用の薬学的組成物
Document Type and Number:
Japanese Patent JP5932972
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition including oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating TLR- and IL-6-mediated diseases, and a pharmaceutical composition including an adzuki bean extract containing the compound or the salt thereof, or a fraction thereof as an active ingredient for preventing or treating TLR- and IL-6-mediated diseases. The adzuki bean extract or the compound of the present invention is derived from a natural resource that has been used as a natural medicine for a long time, and it inhibits TLR-3 and TLR-7 activations induced by Poly(I:C) and Poly(I) which are synthetic analogues of dsRNA and ssRNA, blocks NF-ºB-including signal transduction pathways, and inhibits transcriptional activation and phosphorylation of IL-6-activated inflammatory transcription factor STAT3 without causing side effects, thereby being widely used for the development of prophylactic or therapeutic agents for TLR-and IL-6-mediated diseases, for example, atopic dermatitis or arthritis.
Inventors:
Low munchal
Lee Woo Sung
Oh Hyun Me
Kim Young Min
Ryu Yong Flies
Park Jin
Lee Sang Won
Chou Kyung Oh
Lee Woo Sung
Oh Hyun Me
Kim Young Min
Ryu Yong Flies
Park Jin
Lee Sang Won
Chou Kyung Oh
Application Number:
JP2014508299A
Publication Date:
June 08, 2016
Filing Date:
April 30, 2012
Export Citation:
Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
International Classes:
A61K36/48; A61K8/63; A61K8/97; A61K31/56; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P19/10; A61P29/00; A61P31/14; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; A61Q19/00; A61Q90/00
Domestic Patent References:
| JP2010532789A | ||||
| JP2008081478A |
Foreign References:
| US20070014739 | ||||
| KR1020100042582A | ||||
| WO2007046489A1 |
Other References:
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Phytotherapy Research,1998年,Vol.12, Suppl. 1,p.S138-S142
Brazilian Journal of Pharmacognosy,2010年,Vol.20, No.1,p.113-116
Journal of natural products,1999年,Vol.62, No.10,p.1379-1384
日本農芸化学会誌,1985年,Vol.59, No.9,p.895-900
Journal of natural products.,2006年,Vol.69, No.6,p.887-890
Pharma Medica,2004年,Vol.22, No.12,p.39-44
Circulation Up-to-Date,2010年,Vol.5, No.3,p.274-281
IBD Research,2007年,Vol.1, No.4,p.291-296
医学のあゆみ,2008年,Vol.227, No.5,p.321-325
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara