Title:
ヌクレアーゼの阻害剤としてのピラゾロトリアジン
Document Type and Number:
Japanese Patent JP6313906
Kind Code:
B2
Abstract:
The invention provides compounds represented by the structural formula ( 1 ):
wherein R 1 , R 2 , R 3 and R 4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
Inventors:
Dumbo ASCII, Gili
Niklenkov, Fedor
Shishakova, Alexandra
Havel, stefan
Cleche, Lumire
Carvine, Benoit
Berezovsky, Jan
Lucas, Daniel
Pouch, Camille
Niklenkov, Fedor
Shishakova, Alexandra
Havel, stefan
Cleche, Lumire
Carvine, Benoit
Berezovsky, Jan
Lucas, Daniel
Pouch, Camille
Application Number:
JP2017518407A
Publication Date:
April 18, 2018
Filing Date:
June 17, 2015
Export Citation:
Assignee:
Masalikova Universita
International Classes:
C07D487/04; A61K31/53; A61P7/06; A61P9/00; A61P9/14; A61P35/00; A61P35/02; A61P43/00
Foreign References:
| WO2014081820A1 |
Other References:
JAN SLOUKA,REACTIONS OF 2-(BENZIMIDAZOL-2-YL)ACETONITRILE AND ITS N-ETHOXYCARBONYL DERIVATIVE 以下備考1,COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS,CZECHOSLOVAK CHEMICAL SOCIETY / 以下備考2,1984年,VOL:49, NR:1,,PAGE(S):275 - 279,備考1:WITH SOME AZOL-3-DIAZONIUM SALTS / 備考2:CZECHOSLOVAK ACADEMY OF SCIENCE,URL,http://dx.doi.org/10.1135/cccc19840275
Ledenyova, I. V. et al.,Tetrahedron Letters,2014年 1月 8日,vol.55,p.1239-1242
Elmoghayar, M. R. H. et al.,Liebigs Ann. Chem.,1985年,p.1962-1968
Ulomskii, E. N. et al.,RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,1999年,vol.35, no.9,p.1355-1362
Ledenyova, I. V. et al.,Tetrahedron Letters,2014年 1月 8日,vol.55,p.1239-1242
Elmoghayar, M. R. H. et al.,Liebigs Ann. Chem.,1985年,p.1962-1968
Ulomskii, E. N. et al.,RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,1999年,vol.35, no.9,p.1355-1362
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