Title:
ＥＣＭ組成物、腫瘍微小環境プラットフォームおよびその方法
Document Type and Number:
Japanese Patent JP6378273
Kind Code:
B2
Abstract:
The present disclosure relates to an Extra Cellular Matrix composition specific for cancer type and a tumor microenvironment platform for long term culturing of tumor tissue, wherein said culturing provides human ligands and tumor tissue micro-environment to mimic physiologically relevant signalling systems. The present disclosure further relates to the development of a Clinical Response Predictor and its application in the prognostic field (selection of treatment option for the patient) and translational biology field (development of anticancer drugs). The disclosure further relates to a method of predicting clinical response of a tumor patient to drug(s). The disclosure further relates to a method for screening tumor cells for the presence of specific markers for determining the viability of said cells for indication of tumor status.
Inventors:
Sundaram, Malikaljung
Majundar, Pradeep
Majundar, Biswanus
Jane, Misty
Shagarajan, Sarah Bernan
Pinto, Duncie
Radha Krishnan, Padma
Majundar, Pradeep
Majundar, Biswanus
Jane, Misty
Shagarajan, Sarah Bernan
Pinto, Duncie
Radha Krishnan, Padma
Application Number:
JP2016177434A
Publication Date:
August 22, 2018
Filing Date:
September 12, 2016
Export Citation:
Assignee:
MITRA RXDX INDIA PRIVATE LIMITED
International Classes:
C07K14/78; C07K14/705; C12N1/00; C12N5/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/574
Other References:
Proteomics,2010年,Vol. 10,p. 1886-1890, Supporting Information
The Prostate,2007年,Vol. 67,p. 1308-1317
The Prostate,2007年,Vol. 67,p. 1308-1317
Attorney, Agent or Firm:
Kiyoji Kuzuwa