悪心及び嘔吐の管理のための組成物

Japanese Patent JP6379194

B2

A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3 or. The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).

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JP2005522454	Suppression of lung metastasis by aerosol delivery of p53 gene and anticancer compounds
JP2738414	INDUSTRIAL APPLICABILITY INDUSTRIAL APPLICABILITY An antibody-enzyme conjugate combined with a prodrug for supplying a cytotoxic substance to a tumor cell.

Manon Vranderick
Jean-Luc Saint-Tonju
Michelle Gallo
Eric Gerve

JP2016528268A

August 22, 2018

March 13, 2014

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Ducine Incorporated

A61K31/675; A61K9/08; A61K9/14; A61K9/20; A61K9/48; A61K31/4415; A61K31/525; A61K31/7084; A61P1/08; A61P15/00; A61P43/00

JP2002543106A

US7704542

Therapeutic Drug Monitoring,2011年,Vol.33,No.1,pp.115-119
Nutr.Res.,1992年,Vol.12,No.7,pp.825-831

Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe

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