Title:
膵臓前駆細胞及び機能的β細胞をｈＰＳＣから生成するための方法及び組成物
Document Type and Number:
Japanese Patent JP6397397
Kind Code:
B2
Abstract:
Methods and compositions for producing NKX6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component, optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.
Inventors:
Gordon, Keller
Maria, Christina, Nostro
Audrey, Holzinger
Farida, Saranghi
Maria, Christina, Nostro
Audrey, Holzinger
Farida, Saranghi
Application Number:
JP2015509270A
Publication Date:
September 26, 2018
Filing Date:
April 30, 2013
Export Citation:
Assignee:
UNIVERSITY HEALTH NETWORK
International Classes:
C12N5/074; C12M3/00; C12N5/073; C12N5/0735; C12N5/10; C12Q1/02
Other References:
Cell Research,2009年,Vol. 19,p. 429-438
Stem Cell Rev and Rep,2011年,Vol. 7,p. 532-543
DEVELOPMENT,2011年,Vol. 138,p. 861-871
Stem Cell Rev and Rep,2011年,Vol. 7,p. 532-543
DEVELOPMENT,2011年,Vol. 138,p. 861-871
Attorney, Agent or Firm:
Noritaka Yokota