Title:
ERKの阻害剤および使用方法
Document Type and Number:
Japanese Patent JP6427197
Kind Code:
B2
Abstract:
The present invention provides compounds of formula (II-E) and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as ERK (MAPK). Also provided are methods of using such compounds or compositions, and methods of using these compositions to modulate the activities of one or more of these kinases, especially for therapeutic applications such as the treatment disorders such as cancer.
Inventors:
Li, Liang Shen
Woo, Tao
Fen, Jun
Len, pinda
Riu, Lee
Woo, Tao
Fen, Jun
Len, pinda
Riu, Lee
Application Number:
JP2016546894A
Publication Date:
November 21, 2018
Filing Date:
October 03, 2014
Export Citation:
Assignee:
Kura Oncology, Incorporated
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP63192773A | ||||
| JP2011037841A | ||||
| JP9508126A | ||||
| JP2003500350A | ||||
| JP48057998A | ||||
| JP2010530421A | ||||
| JP2003055376A |
Foreign References:
| WO2012170845A1 | ||||
| US4042704 | ||||
| US20100056800 | ||||
| US20050203063 |
Other References:
TSURUO, T. et al.,Platelet aggregation in the formation of tumor metastasis,Proc. Jpn. Acad., Ser. B,2008年,84,p.189-198
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto