Title:
眼疾患の治療剤又は予防剤
Document Type and Number:
Japanese Patent JP6427497
Kind Code:
B2
Abstract:
Because 3-[(3S,4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6 -diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile suppresses an increase of the retinal vascular permeability induced by VEGF, it can be used as an active ingredient of a therapeutic or preventive agent for various eye diseases involving VEGF, such as age-related macular degeneration, diabetic retinopathy, macular edema, neovascular maculopathy, retinal vein occlusion and neovascular glaucoma.
Inventors:
Hiromi Okigami
Tatsuji Kurose
Yukifumi Fujisawa
Chinami Yoshikawa
Tatsuji Kurose
Yukifumi Fujisawa
Chinami Yoshikawa
Application Number:
JP2015543825A
Publication Date:
November 21, 2018
Filing Date:
October 17, 2014
Export Citation:
Assignee:
Japan Tobacco Inc.
International Classes:
A61K31/519; A61P3/10; A61P27/02; A61P27/06; A61P43/00
Domestic Patent References:
| JP2011046700A | ||||
| JP2013500977A | ||||
| JP2012176930A |
Other References:
The Journal of Pathology,2007年,Vol.170(6),pp.2149-2158
The Journal of Pathology,2012年,Vol.180(3),pp.1243-1253
The Journal of Pathology,2012年,Vol.180(3),pp.1243-1253
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami