Title:
エストロゲン受容体モジュレーターおよびその用途
Document Type and Number:
Japanese Patent JP6465840
Kind Code:
B2
Abstract:
Described herein are compounds of formulae (I) and (VI) that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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Inventors:
Kahraman, Mehmet
Gobek, Stephen, Pee.
Nagasawa, Johnny, Wai.
Smith, Nicholas, Dee.
Gobek, Stephen, Pee.
Nagasawa, Johnny, Wai.
Smith, Nicholas, Dee.
Application Number:
JP2016149008A
Publication Date:
February 06, 2019
Filing Date:
July 28, 2016
Export Citation:
Assignee:
Seragon Pharmaceuticals, Inc.
International Classes:
C07D405/12; A61K31/4025; A61K31/453; A61P5/30; A61P15/08; A61P35/00; A61P43/00
Domestic Patent References:
| JP11500133A | ||||
| JP2007191484A | ||||
| JP2005513133A |
Foreign References:
| WO2004091488A2 | ||||
| US6262270 | ||||
| EP0470310A1 | ||||
| WO2001068634A1 |
Other References:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005年,VOL.15,NO.6,PP.1675-1681
JOURNAL OF MEDICINAL CHEMISTRY,1990年,VOL.33,NO.12,PP.3216-3222
GAUTHIER, S. ET AL,Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution,Journal of Enzyme Inhibition and Medicinal Chemistry,2005年,20(2),165-177
JOURNAL OF MEDICINAL CHEMISTRY,2006年,VOL.49,NO.11,PP.3056-3059
ORGANIC PROCESS RESEARCH & DEVELOPMENT,2009年,VOL.13,NO.1,PP.102-105
JOURNAL OF MEDICINAL CHEMISTRY,2009年,VOL.52,NO.23,PP.7544-7569
ORGANIC PROCESS RESEARCH & DEVELOPMENT,2007年,VOL.11,NO.4,PP.731-738
JOURNAL OF MEDICINAL CHEMISTRY,1990年,VOL.33,NO.12,PP.3216-3222
GAUTHIER, S. ET AL,Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution,Journal of Enzyme Inhibition and Medicinal Chemistry,2005年,20(2),165-177
JOURNAL OF MEDICINAL CHEMISTRY,2006年,VOL.49,NO.11,PP.3056-3059
ORGANIC PROCESS RESEARCH & DEVELOPMENT,2009年,VOL.13,NO.1,PP.102-105
JOURNAL OF MEDICINAL CHEMISTRY,2009年,VOL.52,NO.23,PP.7544-7569
ORGANIC PROCESS RESEARCH & DEVELOPMENT,2007年,VOL.11,NO.4,PP.731-738
Attorney, Agent or Firm:
Kazuhiro Kiyohara