Title:
希少クロノタイプおよびその用途
Document Type and Number:
Japanese Patent JP6513035
Kind Code:
B2
Abstract:
The invention is directed to a method of selecting disease-correlated clonotypes that have a reduced likelihood of producing a false positive signal of relapse when used to monitor minimal residual disease. In accordance with the invention, candidate correlating clonotypes are obtained from a patient, the rarity of each is determined either by comparison with a clonotype database or a clonotype model, and one or more of the rarest of such clonotypes are used to monitor the minimal residual disease.
Inventors:
Francis, Pepin
Faham, Marek
Moorhead, martin
Faham, Marek
Moorhead, martin
Application Number:
JP2015558958A
Publication Date:
May 15, 2019
Filing Date:
February 20, 2014
Export Citation:
Assignee:
Adaptive Biotechnology Corporation
International Classes:
C12Q1/6883; C12N15/12; C12N15/13
Foreign References:
| US6416948 | ||||
| WO2011139371A1 |
Other References:
Science translational medicine,2012年,Vol.4,p.151-157
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Kaoru Takahashi
Nao Oda
Akiyo Iwahori
Kaoru Takahashi