Title:
エクジソン受容体複合体を通して外因性遺伝子の発現を調節するためのキラルジアシルヒドラジンリガンド
Document Type and Number:
Japanese Patent JP6516826
Kind Code:
B2
Abstract:
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
Inventors:
Hohmann, Robert, Yi.
Lee, Bing
Lee, Bing
Application Number:
JP2017249527A
Publication Date:
May 22, 2019
Filing Date:
December 26, 2017
Export Citation:
Assignee:
Intrexon Corporation
International Classes:
A61K31/166; A61K31/357; A61K31/36; A61K47/14; A61K48/00; C12N15/63
Domestic Patent References:
| JP2006517964A | ||||
| JP2152922A |
Foreign References:
| WO2004078924A1 |
Other References:
村上尚道,光学活性体の利用,光学異性体の分離〔季刊 化学総説 No.6〕,1999年 6月10日,p.212-213
改訂 医薬品添加物ハンドブック,2007年 2月,p.582-586
立体化学,1979年,第8刷,第39-41頁
改訂 医薬品添加物ハンドブック,2007年 2月,p.582-586
立体化学,1979年,第8刷,第39-41頁
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Emiko Nishizawa
Yasuhito Suzuki
Norio Omori
Emiko Nishizawa
Yasuhito Suzuki