Title:
多能性幹細胞から誘導した細胞を精製するための方法
Document Type and Number:
Japanese Patent JP6527487
Kind Code:
B2
Abstract:
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.
Inventors:
Karanu, Francis
Alieza, Rezania
Alieza, Rezania
Application Number:
JP2016110884A
Publication Date:
June 05, 2019
Filing Date:
June 02, 2016
Export Citation:
Assignee:
Janssen Biotech, Inc.
International Classes:
C12N5/071; A61K35/39; C12N5/0735; C12Q1/02
Domestic Patent References:
| JP2009528066A | ||||
| JP6013196B2 |
Foreign References:
| US20090263896 | ||||
| WO2009070592A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki
Junko Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki