Title:
化学療法耐性を克服するためのウィルホルリドＡの使用
Document Type and Number:
Japanese Patent JP6529138
Kind Code:
B2
Abstract:
The invention provides compositions comprising wilforlide A for overcoming drug resistance in cancer therapy, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods and compositions for treating a cancer are disclosed. The method administers to a patient in need thereof a combination of wilforlide A and a chemotherapeutic drug. Wilforlide A and chemotherapeutic drug are administered in a combined amount effective to treat the cancer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug alone.
Inventors:
Chow, Moses, Shin, Sam
Fan, in
One, Gee, Jun
Fan, in
One, Gee, Jun
Application Number:
JP2016542816A
Publication Date:
June 12, 2019
Filing Date:
September 12, 2014
Export Citation:
Assignee:
Western University of Health Sciences
International Classes:
A61K31/365; A61K9/08; A61K31/517; A61K47/14; A61K47/40; A61P35/00; A61P43/00
Domestic Patent References:
| JP6087760A | ||||
| JP2005330253A |
Other References:
Extract of Tripterygium wilfordii sensitizes drug resistant prostate cancer cells to docetaxel,J. Clin. Pharmacol,2011年,Vol.51, No.9,pp1364
Abstract 1534: Bioassay-guided identification of novel P-glycoprotein inhibitors from traditional Chinese medicines,Cancer Research,2010年,Vol.70, No.8
Simple method for determination of five terpenoids from different parts of Tripterygium wilfordii and its preparations by HPLC coupled with evaporative light scattering detection,J Sep Sci.,2007年,Vol.30, No.9,pp1284-1291
Abstract 1534: Bioassay-guided identification of novel P-glycoprotein inhibitors from traditional Chinese medicines,Cancer Research,2010年,Vol.70, No.8
Simple method for determination of five terpenoids from different parts of Tripterygium wilfordii and its preparations by HPLC coupled with evaporative light scattering detection,J Sep Sci.,2007年,Vol.30, No.9,pp1284-1291
Attorney, Agent or Firm:
Asamura patent office