Title:
ＦｃＲｎアンタゴニスト及び使用方法
Document Type and Number:
Japanese Patent JP6554473
Kind Code:
B2
Abstract:
Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
Inventors:
Peter Ulrikfts
Christophe Blanche Toto
Torsten Drayel
Johannes De Haard
E. Sally Ward Obel
Nicholas G. H. Ongenae
Christophe Blanche Toto
Torsten Drayel
Johannes De Haard
E. Sally Ward Obel
Nicholas G. H. Ongenae
Application Number:
JP2016542697A
Publication Date:
July 31, 2019
Filing Date:
December 23, 2014
Export Citation:
Assignee:
Argen-X Bee Bie A
The Board of Regents of the University of Texas System
The Board of Regents of the University of Texas System
International Classes:
C12N15/13; A61K39/395; A61K45/00; A61K45/06; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/00; A61P7/04; A61P7/06; A61P9/00; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/14; A61P19/00; A61P19/02; A61P19/04; A61P21/00; A61P21/02; A61P25/00; A61P25/08; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/06; C07K16/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/02
Domestic Patent References:
| JP2013507128A |
Foreign References:
| WO2013074598A1 |
Attorney, Agent or Firm:
Toru Ishikawa