Title:
ＥＧＦＲの発現をサイレンシングするためのＤＮＡザイム
Document Type and Number:
Japanese Patent JP6574136
Kind Code:
B2
Abstract:
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.
Inventors:
Yang, Pan-Chill
Rye, Way-Yoon
Peck, conan
Chang, Chen-ju
Chen, Jiyuan
Yang, Shen-Chen
Rye, Way-Yoon
Peck, conan
Chang, Chen-ju
Chen, Jiyuan
Yang, Shen-Chen
Application Number:
JP2015552899A
Publication Date:
September 18, 2019
Filing Date:
January 14, 2014
Export Citation:
Assignee:
National Taiwan University
International Classes:
C12N15/113; A61K31/4709; A61K31/517; A61K31/53; A61K31/5377; A61K31/7088; A61K45/00; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Domestic Patent References:
| JP2008504809A | ||||
| JP2003521943A |
Foreign References:
| WO2012043633A1 | ||||
| WO2005108570A1 | ||||
| WO2003095648A1 |
Other References:
BMC Medicine, 2012, Vol.10, No.28, pp.1-15
Nature Reviews Cancer, 2007, Vol.7, pp.169-181
Biochemical and Biophysical Research Communications, 2012.12.22, Vol.431, pp.623-629
Biochemical and Biophysical Research Communications, 2009, Vol.378, pp.230-234
Expert Opinion on Drug Discovery, 2010, Vol.16, pp.709-722
Nucleic Acids Research, 2007, Vol.35, No.9, pp.2885-2892
Nature Reviews Cancer, 2007, Vol.7, pp.169-181
Biochemical and Biophysical Research Communications, 2012.12.22, Vol.431, pp.623-629
Biochemical and Biophysical Research Communications, 2009, Vol.378, pp.230-234
Expert Opinion on Drug Discovery, 2010, Vol.16, pp.709-722
Nucleic Acids Research, 2007, Vol.35, No.9, pp.2885-2892
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto