Title:
免疫細胞の能力を増強する方法
Document Type and Number:
Japanese Patent JP6585041
Kind Code:
B2
Abstract:
Embodiments of the invention employ methods and compositions for enhancing potency of immune cells that express one or more therapeutic proteins. In certain cases, the methods modulate expression of a CAR transgene in an immune cell, such as a T cell. Specific embodiments employ the exposure of cells and/or individuals to be treated with the cells with an effective amount of at least one agent that upregulates expression of the therapeutic protein, such as a mitogen, histone deacetylase inhibitor, and or DNA methyltransferase inhibitor.
Inventors:
Vera Valdes, Juan Fernando
Brenner, Malcolm
Anura sapan, Usana rat
Brenner, Malcolm
Anura sapan, Usana rat
Application Number:
JP2016527147A
Publication Date:
October 02, 2019
Filing Date:
July 18, 2014
Export Citation:
Assignee:
BAYLOR COLLEGE OF MEDICINE
International Classes:
A61K35/17; A61K31/166; A61K31/19; A61K31/192; A61K31/353; A61K31/706; A61K35/15; A61K38/02; A61K38/19; A61K39/395; A61K45/00; A61P35/00; A61P37/04; A61P43/00; C12N5/0783
Domestic Patent References:
| JP2011522814A |
Foreign References:
| WO2013050596A1 |
Other References:
Molecular Therapy,2012年 5月,Vol.12, Suppl.1,p.S77,No.196
Bone marrow transplantation,2013年 4月,Vol.48, Suppl.2,p.S15,No.O150
Bone marrow transplantation,2013年 4月,Vol.48, Suppl.2,p.S15,No.O150
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office