Title:
１−（３，５−ジクロロ−４−フルオロ−フェニル）−２，２，２−トリフルオロ−エタノンを調製するプロセス
Document Type and Number:
Japanese Patent JP6640210
Kind Code:
B2
Abstract:
The invention relates to a a process for the preparation of a compound of formula I comprising a) reacting a compound of formula II in the presence of magnesium or an organometallic reagent of formula III R1M2X (III), wherein R1 is CI-C4alkyl; M2 is Li or Mg and X is halogen or absent; with a compound of formula IV CF3-C(O)-R2 (IV), wherein R2 is halogen, hydroxyl, CI-C4alkoxy, (di-CI-C4alkyl)amino, OC(O)CF3, phenoxy or OM1; wherein M1 is Lithium, Magnesium, Sodium or Potassium; to a compound of formula V, and b) reacting the compound of formula V with alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I.
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Inventors:
Smitz helmars
Application Number:
JP2017519851A
Publication Date:
February 05, 2020
Filing Date:
October 08, 2015
Export Citation:
Assignee:
Syngenta Participations Age
International Classes:
C07C45/63; C07C45/45; C07C49/80
Domestic Patent References:
| JP2014507459A | ||||
| JP2011519827A |
Foreign References:
| DE102009049419A1 | ||||
| WO2013169622A1 | ||||
| EP0211561A1 |
Attorney, Agent or Firm:
Shinichiro Tanaka
Disciple Maru Ken
▲吉▼田 和彦
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Takamitsu Hoshino
Disciple Maru Ken
▲吉▼田 和彦
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Takamitsu Hoshino