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Document Type and Number:
Japanese Patent JP6646653
Kind Code:
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.

Eagle, Gina
Gupta, Renu
Application Number:
Publication Date:
February 14, 2020
Filing Date:
May 15, 2015
Export Citation:
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Insmed Incorporated
International Classes:
A61K31/7036; A61K9/12; A61K9/127; A61K9/133; A61K31/395; A61K47/24; A61P11/00; A61P31/04
Domestic Patent References:
Foreign References:
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito