Title:
急性骨髄性白血病の治療方法
Document Type and Number:
Japanese Patent JP6676182
Kind Code:
B2
Abstract:
A method of treating acute myeloid leukemia (AML), including the steps of (i) measuring a density of blast cells in the peripheral blood and the bone marrow of a subject with AML; (ii) administering to the subject a CXCR4 antagonist; and (iii) administering to the subject a therapeutically effective amount of the CXCR4 antagonist and a therapeutically effective amount of a chemotherapeutic agent, if the blast cell density in the peripheral blood is less than 10% of the total peripheral white blood cells, or at least five-fold lower than the blast cell density in the bone marrow, or at least two-fold higher one day or more following step (ii).
Inventors:
Pereg, Yaron
Amed, Pered
Amed, Pered
Application Number:
JP2018544337A
Publication Date:
April 08, 2020
Filing Date:
February 23, 2017
Export Citation:
Assignee:
BioLineRx Ltd.
Biokine Therapeutics Ltd.
Biokine Therapeutics Ltd.
International Classes:
A61K38/12; A61K31/7068; A61P35/02
Domestic Patent References:
| JP6294459B2 |
Foreign References:
| WO2015063768A1 |
Other References:
Blood,2009年,Vol.113, No.24,p.6206-6214
Attorney, Agent or Firm:
Takeshi Ebe
Kazuo Asahi
Kazuo Asahi