Title:
乳酸脱水素酵素阻害剤およびそれを含有する抗てんかん剤
Document Type and Number:
Japanese Patent JP6681072
Kind Code:
B2
Abstract:
The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (III); i.e., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the invention has these compounds as an active ingredient.
Inventors:
Go Inoue
Sada Nagisa
Sada Nagisa
Application Number:
JP2016574804A
Publication Date:
April 15, 2020
Filing Date:
February 09, 2016
Export Citation:
Assignee:
Okayama University
International Classes:
A61K31/36; A61K31/4025; A61K31/404; A61K31/41; A61K31/4155; A61K31/4162; A61K31/4178; A61K31/42; A61K31/422; A61K31/425; A61K31/427; A61K31/433; A61K31/439; A61K31/443; A61K31/496; A61K31/506; A61P25/08; A61P43/00
Domestic Patent References:
| JP2013510106A |
Foreign References:
| WO2014115764A1 | ||||
| US20130079336 | ||||
| US4209517 |
Other References:
Asian Journal of Chemistry,2010年,Vol.22, No.1,P.589-592
Bioorganic & Medicinal Chemistry,2005年,Vol.13,P.4007-4013
Bioorganic & Medicinal Chemistry,2005年,Vol.13,P.4007-4013
Attorney, Agent or Firm:
Patent corporation ssinpat