Title:
変性された潜在関連蛋白質構成物
Document Type and Number:
Japanese Patent JP6687548
Kind Code:
B2
Abstract:
The present invention provides a fusion protein comprising a latency associated peptide (LAP), a pharmaceutically active agent and an amino acid sequence comprising a dimerisation domain, wherein the LAP and the pharmaceutically active agent are connected by an amino acid sequence comprising a proleolytic cleavage site. Also provided are nucleic acids enclosing such fusion proteins, process for their preparation, pharmaceutical compositions, kits and uses thereof in medicine.
Inventors:
Chana Hobski Uty
Murren Lisa
Adams Gillian
Gold david james
Muhammad Hazane
Murren Lisa
Adams Gillian
Gold david james
Muhammad Hazane
Application Number:
JP2016574456A
Publication Date:
April 22, 2020
Filing Date:
June 26, 2015
Export Citation:
Assignee:
Steel Six Therapeutics Limited
International Classes:
C07K19/00; A61K35/12; A61K38/16; A61K38/18; A61K38/43; A61K38/55; A61K39/395; A61K48/00; A61P29/00; A61P35/00; C07K14/47; C07K14/495; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62
Domestic Patent References:
| JP2011507498A | ||||
| JP2004520031A | ||||
| JP2009510166A | ||||
| JP2013532954A |
Other References:
Lisa Mullen et al.,Development of latent cytokine fusion proteins,Fusion protein technologies for biopharmaceuticals,2013年,pp.237-252
Adam M. Koppel et al.,Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity,The Journal of Biological Chemistry,1998年,Vol.273, No.25,pp.15708-15713
Adam M. Koppel et al.,Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity,The Journal of Biological Chemistry,1998年,Vol.273, No.25,pp.15708-15713
Attorney, Agent or Firm:
Hisashi Tsuji