Title:
ヒストンデアセチラーゼの阻害剤としての大環状分子のチオエステルプロドラッグ
Document Type and Number:
Japanese Patent JP6691958
Kind Code:
B2
Abstract:
The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.
Inventors:
Piscopio, Anthony Dee.
Application Number:
JP2018504878A
Publication Date:
May 13, 2020
Filing Date:
May 18, 2017
Export Citation:
Assignee:
On Cure, Incorporated
International Classes:
C07K5/00; A61K38/07; A61P25/00; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00
Foreign References:
| WO2015183897A1 | ||||
| WO2015027959A1 | ||||
| US20150010541 | ||||
| US8933195 |
Other References:
Bioorg. Med. Chem.,2011年 6月15日,Vol.19, No.12,p.3650-3658
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Saori Oga
Yasuhito Suzuki
Norio Omori
Saori Oga
Yasuhito Suzuki