Title:
療法の適合性を評価するための改善された患者の層別化
Document Type and Number:
Japanese Patent JP6700186
Kind Code:
B2
Abstract:
A method for stratification of a patient for assessing suitability of a therapy for the patient suffering from an ER (estrogen receptor) and/or PR (progesterone receptor) positive and HER2 (human epidermal growth factor receptor 2) negative cancer, the therapy being directed towards a signaling pathway, includes: (i) determining an activation status of an ER and/or PR signaling pathway by applying a Proximity Ligation Assay to detect in a tissue sample of the patient a presence of at least one member of the ER family, the at least one member being part of a transcription factor complex, and at least one protein selected from a group consisting of TAFs (TATA-binding protein associated factor), TBP (TATA-box binding protein), POLII (RNA polymerase II), TFII (transcription factor H), p300, CREB (cyclic-AMP response element-binding protein), and CBP (CREB binding protein), wherein the at least one protein is part of the same transcription factor complex.
Inventors:
Halter, darphite
Wimberger-Friedle, Reinhold
Juan de Strupe, Anya
Fan hemelt, flakes
Dam-De Fehn, Heskke Christina
Wimberger-Friedle, Reinhold
Juan de Strupe, Anya
Fan hemelt, flakes
Dam-De Fehn, Heskke Christina
Application Number:
JP2016547165A
Publication Date:
May 27, 2020
Filing Date:
January 21, 2015
Export Citation:
Assignee:
KONINKLIJKE PHILIPS N.V.
International Classes:
G01N33/574; C12Q1/02; G01N33/48; G01N33/53
Domestic Patent References:
| JP2010500577A | ||||
| JP2007304102A | ||||
| JP2013523105A |
Foreign References:
| WO2000066767A1 |
Other References:
POULARD, C. et al.,Activation of rapid oestrogen signalling in aggressive human breast cancers,EMBO MOLECULAR MEDICINE,2012年11月 2日,Vol.4/No.11,pp.1200-1213, Supplemental Data
Attorney, Agent or Firm:
Tadashige Ito
Tadahiko Ito
Shinsuke Onuki
Tadahiko Ito
Shinsuke Onuki