Title:
ＨＰＶ誘発の侵食癌および高度前駆病変の分子診断マーカーＰＲＤＭ１４およびＦＡＭ１９Ａ４
Document Type and Number:
Japanese Patent JP6703400
Kind Code:
B2
Abstract:
The invention relates to method for detecting HPV-induced high-grade precancerous lesions and HPV-induced invasive cancers, said method comprising detection of hypermethylation in the PRDM14 and/or FAM19A4 gene in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential and HPV-induced invasive cancers. The invention further comprises the use of the PRDM14 and/or FAM19A4 gene in such a method and a testkit for the detection of PRDM14 and/or FAM19A4 methylation.
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Inventors:
Meyer, Christopherus Johannes Lambertus Maria
Snidels, Petrus Josefs, Ferdinandus
Steen Bergen, Renske Daniela Maria
Snidels, Petrus Josefs, Ferdinandus
Steen Bergen, Renske Daniela Maria
Application Number:
JP2015536738A
Publication Date:
June 03, 2020
Filing Date:
October 14, 2013
Export Citation:
Assignee:
SELF-SCREEN B.V.
International Classes:
C12Q1/68; C12N15/113; C12N15/12; C12Q1/34; C12Q1/686; C12Q1/6886; G01N33/50
Other References:
Wilting SM et al,Methylation-mediated silencing and tumor suppressive function of hsa-miR-124 in cervical cancer,Molecular Cancer,2010年,9:167
Teschendorff AE et al,Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation,Genome Medicine,2012年,4:24
Teschendorff AE et al,Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation,Genome Medicine,2012年,4:24
Attorney, Agent or Firm:
Fukami patent office