Title:
アセチル化スカベンジャーを含むＴａｔ−ＮＲ２Ｂ９ｃの凍結乾燥製剤
Document Type and Number:
Japanese Patent JP6707469
Kind Code:
B2
Abstract:
The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c including histidine, trehalose and lysine. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
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Inventors:
Garman, Jonathan David
Hoffman, Frieder
Hoffman, Frieder
Application Number:
JP2016569613A
Publication Date:
June 10, 2020
Filing Date:
May 28, 2015
Export Citation:
Assignee:
Nono Incorporated
International Classes:
A61K38/10; A61K9/08; A61K9/19; A61K47/18; A61K47/26; A61P9/10
Domestic Patent References:
| JP2009545543A | ||||
| JP2013525406A | ||||
| JP2009525986A | ||||
| JP2012519712A | ||||
| JP2012511540A | ||||
| JP2009531371A | ||||
| JP2013511510A |
Foreign References:
| WO2012021854A1 | ||||
| WO2011017070A1 | ||||
| WO2012165917A1 | ||||
| WO2012158978A1 |
Other References:
CARPENTER, J.F. et al.,"RATIONAL DESIGN OF STABLE LYOPHILIZED PROTEIN FORMULATIONS: THEORY AND PRACTICE",PHARM. BIOTECHNOL.,2002年 1月 1日,Vol.13,No.1,p.109-133,ISSN 1078-0467
Attorney, Agent or Firm:
sk patent corporation
Akihiko Okuno
Hiroyuki Ito
Akihiko Okuno
Hiroyuki Ito