Title:
クローディン−５産生促進剤及びクローディン−５産生促進用経口用組成物
Document Type and Number:
Japanese Patent JP6736645
Kind Code:
B2
Abstract:
To provide a Tie2 activating agent, neovascularization inhibitory agent, blood vessel maturation agent, blood vessel normalization agent, and blood vessel stabilization agent, claudin-5 production promoting agent, lymphatic vessel stabilization agent, eNOS production promoting agent, blood vessel expansion agent, and platelet aggregation inhibitory agent, and a pharmaceutical composition, which have high safety and have excellent Tie2 activating action, neovascularization inhibitory action, blood vessel maturation action, blood vessel normalization action, and blood vessel stabilization action, claudin-5 production promoting action, lymphatic vessel stabilization action, eNOS production promoting action, blood vessel expansion action, and platelet aggregation inhibitory action.SOLUTION: The present invention provides a claudin-5 production promoting action, blood vessel stabilization agent, and lymphatic vessel stabilization agent, and oral composition for promoting claudin-5 production, which contain piperine.SELECTED DRAWING: None
Inventors:
Nobuaki Oto
Hiroyasu Iwahashi
Hiroyasu Iwahashi
Application Number:
JP2018230819A
Publication Date:
August 05, 2020
Filing Date:
December 10, 2018
Export Citation:
Assignee:
Maruzen Pharmaceutical Co., Ltd.
International Classes:
A61K31/4525; A61P9/14; A61P43/00
Domestic Patent References:
| JP2013035821A | ||||
| JP6452552B2 |
Other References:
Int. J. Pharm. Sci. Rev. Res.,2010年,Vol.5, No.1,p.67-76
Frontiers in Cell and Developmental Biology,2018年 2月15日,Vol.6:10,p.1-12,doi:10.3389/fcell.2018.00010
Prostaglandins, Leukotrienes and Essential Fatty Acids,2004年,Vol.70,p.521-528
J. Soc. Cosmet. Jpn.,2012年,Vol.46,p.188-196
Frontiers in Cell and Developmental Biology,2018年 2月15日,Vol.6:10,p.1-12,doi:10.3389/fcell.2018.00010
Prostaglandins, Leukotrienes and Essential Fatty Acids,2004年,Vol.70,p.521-528
J. Soc. Cosmet. Jpn.,2012年,Vol.46,p.188-196
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda