Title:
化合物Ｎ−（３，５−ジメチルフェニル）−Ｎ’−（２−トリフルオロメチルフェニル）グアニジンの調製方法
Document Type and Number:
Japanese Patent JP6748188
Kind Code:
B2
Abstract:
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.
Inventors:
Amato, Jose
Application Number:
JP2018506997A
Publication Date:
August 26, 2020
Filing Date:
August 10, 2016
Export Citation:
Assignee:
CHEMO RESEARCH,S.L.
International Classes:
C07C277/08; C07C279/18
Domestic Patent References:
| JP2014530813A |
Other References:
塩路雄作,固形製剤の製造技術,東京:シーエムシー出版,2003年 1月27日,普及版,pp. 9, 12-13,ISBN 4-88231-783-4
Stephen BYRN et al,Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations,Pharmaceutical Research,1995年 7月,Vol.12, No.7,p.945-954
浅原 照三,溶剤ハンドブック,株式会社 講談社,1985年,p.47-51
Stephen BYRN et al,Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations,Pharmaceutical Research,1995年 7月,Vol.12, No.7,p.945-954
浅原 照三,溶剤ハンドブック,株式会社 講談社,1985年,p.47-51
Attorney, Agent or Firm:
Hiroe Associates Patent Office