Title:
疾患に対する免疫反応を誘導するための併用療法
Document Type and Number:
Japanese Patent JP6767029
Kind Code:
B2
Abstract:
The present invention concerns combinations of two or more agents for inducing an immune response to cancer or infectious disease. Agents may include leukocyte redirecting complexes, antibody-drug conjugates, interferons (preferably interferon-a), and/or checkpoint inhibitor antibodies. The leukocyte redirecting complexes have at least one binding site for a leukocyte antigen and at least one binding site for an antigen on a diseased cell or pathogen. Preferably, the complex is a DNL™ complex. More preferably, the complex comprises a bispecific antibody (bsAb). Most preferably, the bsAb is an anti-CD3 x anti-CD 19 bispecific antibody, although antibodies against other leukocyte antigens and/or disease-associated antigens may be used. The complex is capable of targeting effector T cells, NK cells, monocytes or neutrophils to induce leukocyte-mediated cytotoxicity of cells associated with cancer or infectious disease. The cytotoxic immune response is enhanced by co- administration of interferon, checkpoint inhibitor antibody and/or ADC.
More Like This:
Inventors:
Chan, Chen-Shin
Goldenberg, David, M.
Rossi, Edmund, A.
Rossi, Diane
Goldenberg, David, M.
Rossi, Edmund, A.
Rossi, Diane
Application Number:
JP2019038757A
Publication Date:
October 14, 2020
Filing Date:
March 04, 2019
Export Citation:
Assignee:
Ivy Pharmaceuticals, Inc.
International Classes:
A61K39/395; A61K38/21; A61K47/65; A61K47/68; A61P35/00; A61P35/02; A61P37/04; A61P43/00
Domestic Patent References:
| JP2011530536A |
Foreign References:
| WO2012143524A1 | ||||
| US20110020273 |
Other References:
IMMUNOMEDICS DEVELOPS T-CELL REDIRECTING BISPECIFICANTIBODIES AS POTENTIAL THERAPEUTICS FOR SOLID AN,[online],2013年 4月10日,[平成29年7月28日検索], インターネット
FLIEGER D,CANCER IMMUNOLOGY AND IMMUNOTHERAPY,ドイツ,2000年10月,V49 N8,P441-448
FLIEGER D,CANCER IMMUNOLOGY AND IMMUNOTHERAPY,ドイツ,2000年10月,V49 N8,P441-448
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda