Title:
多発性硬化症の治療方法
Document Type and Number:
Japanese Patent JP6786486
Kind Code:
B2
Abstract:
Provided herein are methods of treating multiple sclerosis with a fumarate, wherein the fumarate is a dialkyl fumarate, a monoalkyl fumarate, a combination of a dialkyl fumarate and a monoalkyl fumarate, a prodrug of monoalkyl fumarate, a deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing, or a combination of any of the foregoing. The methods provided herein improve the safety of treatment by informing and monitoring patients undergoing treatment regarding progressive multifocal leukoencephalopathy, and/or by monitoring lymphocyte count.
Inventors:
Novas, Mark
Zan, Louis (Rei)
Zan, Louis (Rei)
Application Number:
JP2017526549A
Publication Date:
November 18, 2020
Filing Date:
November 16, 2015
Export Citation:
Assignee:
Biogen MA Inc.
International Classes:
A61K31/225; A61P25/00
Other References:
DEPARTMENT OF VETERANS AFFAIRS VETERANS HEALTH ADMINISTRATION (VHA) PHARMACY BENEFITS 以下備考,NATIONAL PBM BULLETIN,2014年11月 7日,P1,MANAGEMENT SERVICES (PBM), MEDICAL ADVISORY PANEL (MAP), AND CENTER FOR MEDICATION SAFETY 以下省略,URL,https://www.pbm.va.gov/PBM/vacenterformedicationsafety/nationalpbmbulletin/Dimethyl_Fumarate_Tecfidera_and_PML_Resulting_in_Death_NATIONAL_PBM_Bulletin.pdf
ANNEX I: SUMMARY OF PRODUCT CHARACTERISTICS,[ONLINE],2014年10月11日,P1-49,TECFIDERA,URL,https://web.archive.org/web/20141011193051/http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002601/WC500162069.pdf
ANNEX I: SUMMARY OF PRODUCT CHARACTERISTICS,[ONLINE],2014年10月11日,P1-49,TECFIDERA,URL,https://web.archive.org/web/20141011193051/http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002601/WC500162069.pdf
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita