Title:
抗がん活性を有する６−オキソ−１，６−ジヒドロ−ピリダジン誘導体とキナゾリン誘導体との組み合わせ
Document Type and Number:
Japanese Patent JP6791855
Kind Code:
B2
Abstract:
A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with 4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethyl-phenyl)-ethylamino]-quinazoline-8-carboxylic acid amide.
Inventors:
Bratt, Fried Helm
Frize-Hamim, Manja
Frize-Hamim, Manja
Application Number:
JP2017531476A
Publication Date:
November 25, 2020
Filing Date:
November 12, 2015
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K31/506; A61K31/517; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP2014034534A | ||||
| JP2012524088A | ||||
| JP2010532774A | ||||
| JP2013544257A |
Foreign References:
| WO2013139423A1 | ||||
| WO2014056566A1 |
Other References:
cMET activation and EGFR-directed therapy resistance in triple-negative breast cancer,Journal of Cancer,2014年10月15日,5 (9),745-753
Targeting Met signaling to overcome human cancer cell resistance to radiation,Cancer Research,2013年,Vol. 73, No. 8, Supp. SUPPL. 1.
A Selective Small Molecule c-Met Inhibitor, PHA665752, Cooperates with Rapamycin,Clinical Cancer Research,2005年,11,2312-2319
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells,Biochemical and Biophysical Research Communications,2013年,431 (2),264-269
EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors,Clinical Cancer Research,2013年,19 (11),2941-2951
Identification of brain penetrant p70S6K/Akt inhibitor MSC2363318A,Molecular Cancer Therapeutics,2013年,Vol. 12, No. 11, Supp. SUPPL. 1
The novel kinase inhibitor EMD1214063 is effective against neuroblastoma,Investigational New Drugs,2014年10月,32 (5),815-824
Targeting Met signaling to overcome human cancer cell resistance to radiation,Cancer Research,2013年,Vol. 73, No. 8, Supp. SUPPL. 1.
A Selective Small Molecule c-Met Inhibitor, PHA665752, Cooperates with Rapamycin,Clinical Cancer Research,2005年,11,2312-2319
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells,Biochemical and Biophysical Research Communications,2013年,431 (2),264-269
EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors,Clinical Cancer Research,2013年,19 (11),2941-2951
Identification of brain penetrant p70S6K/Akt inhibitor MSC2363318A,Molecular Cancer Therapeutics,2013年,Vol. 12, No. 11, Supp. SUPPL. 1
The novel kinase inhibitor EMD1214063 is effective against neuroblastoma,Investigational New Drugs,2014年10月,32 (5),815-824
Attorney, Agent or Firm:
Kiyoji Kuzuwa
Previous Patent: 組織適用におけるＬＧＲ４、ＬＧＲ５およびＬＧＲ６発現上皮幹細胞を用...
Next Patent: ポリ（メタ）アクリレートベースのプライマー層を備える接着性物品及び...
Next Patent: ポリ（メタ）アクリレートベースのプライマー層を備える接着性物品及び...