Title:
ムスカリンＭ１及び／またはＭ４受容体のアゴニストとしてのオキシム化合物
Document Type and Number:
Japanese Patent JP6799596
Kind Code:
B2
Abstract:
This invention relates to compounds that are agonists of the muscarinic M1 and/or M4 receptor and which are useful in the treatment of diseases mediated by the muscarinic M1 and M4 receptors. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formulawhere p; q; X1; X2; Y; R1; R2; R3; R4; R5 and R6 are as defined herein.
Inventors:
Brown, Giles Albert
Taehan, Benjamin Gerard
Taehan, Benjamin Gerard
Application Number:
JP2018522540A
Publication Date:
December 23, 2020
Filing Date:
November 02, 2016
Export Citation:
Assignee:
Heptares Therapeutics Limited
International Classes:
C07D401/04; A61K31/454; A61K31/55; A61P25/00; A61P25/04; A61P25/28; A61P25/30; A61P43/00
Domestic Patent References:
| JP2015528489A | ||||
| JP2015501799A | ||||
| JP2008521821A | ||||
| JP2000501117A | ||||
| JP11501014A | ||||
| JP2002543186A |
Other References:
Meanwell, N. A.,Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design,Journal of Medicinal Chemistry,2011年,54,pp. 2529-2591,DOI: 10.1021/jm1013693
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Akiko Yamaguchi
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Akiko Yamaguchi